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The role of adenine nucleotide and its metabolites in regulating the homeostasis of glucose and lipid metabolism / 生理学报
Acta Physiologica Sinica ; (6): 707-722, 2021.
Artículo en Chino | WPRIM | ID: wpr-921274
ABSTRACT
Glucose and lipid metabolism is the most fundamental metabolic activity of higher organisms. This process is affected by both genetic polymorphisms and environmental factors. Excessive uptake and accumulation of lipids lead to obesity and disorder of glucose metabolic homeostasis characterized by insulin resistance and hyperglycemia, suggesting that the cross-regulation between lipid and glucose metabolism happens precisely at organ, cellular and molecular levels by known mechanisms. Adenine nucleotides and their metabolites have emerged as mediators in the mutual regulation of glucose and lipid metabolism. This review summarizes the roles of purinergic signaling induced by fatty acids in glucose metabolism and the development of type 2 diabetes.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Resistencia a la Insulina / Nucleótidos de Adenina / Diabetes Mellitus Tipo 2 / Metabolismo de los Lípidos / Glucosa / Homeostasis Límite: Humanos Idioma: Chino Revista: Acta Physiologica Sinica Año: 2021 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Resistencia a la Insulina / Nucleótidos de Adenina / Diabetes Mellitus Tipo 2 / Metabolismo de los Lípidos / Glucosa / Homeostasis Límite: Humanos Idioma: Chino Revista: Acta Physiologica Sinica Año: 2021 Tipo del documento: Artículo