Unfolded protein response signaling in mitochondria / 生理学报
Acta Physiologica Sinica
; (6): 835-844, 2021.
Article
en Zh
| WPRIM
| ID: wpr-921287
Biblioteca responsable:
WPRO
ABSTRACT
The mitochondrial unfolded protein response is an important component of the mitochondrial protein quality control program. It can effectively remove unfolded or misfolded proteins under stress, and maintain a stable and healthy mitochondrial pool. The mitochondrial unfolded protein response is coordinated by multiple signaling pathways. The classical ATF4/ATF5-CHOP pathway is induced by accumulation of unfolded or misfolded proteins in the mitochondrial matrix, which reduces stress toxicity by regulating molecular chaperones and proteases. Sirt3-FOXO3a-SOD2 pathway, located in the mitochondrial matrix, plays an important role in anti-oxidative damage. The ERα-NRF1-HTRA2 pathway mainly removes unfolded proteins in the mitochondrial membrane space and improves the quality control of mitochondrial proteins. These three signaling pathways work both independently and cooperatively to enhance mitochondrial capacity and maintain health under stress.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Transducción de Señal
/
Estrés Oxidativo
/
Proteínas Mitocondriales
/
Respuesta de Proteína Desplegada
/
Mitocondrias
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2021
Tipo del documento:
Article