Rb pathway alteration and E2F-1 expression in epithelial ovarian cancer / 부인종양
Korean Journal of Gynecologic Oncology
;
: 299-307, 2007.
Artículo
en Coreano
| WPRIM
| ID: wpr-92177
ABSTRACT
OBJECTIVE:
To evaluate the clinicopathological implications of Rb pathway alteration and E2F-1 expression in Epithelial ovarian cancer using immunohistochemical staining.METHODS:
Tissue samples (n=72) were collected after staging operation between 1998 and 2004.RESULTS:
In 72 cases, the overall expression of pRb, and E2F-1 were 59.7% (43/72), and 58.3% (42/72), respectively. pRb expression was inversely correlated with stage, histologic grade and mitotic index. E2F-1 expression was correlated with advanced stages, high grade, mitotic index, Ki-67 labeling index (LI).CONCLUSION:
We suggest that Rb pathway alteration and E2F-1 expression could play roles as a new prognostic factors in Epithelial ovarian cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Ováricas
/
Índice Mitótico
Tipo de estudio:
Estudio pronóstico
Idioma:
Coreano
Revista:
Korean Journal of Gynecologic Oncology
Año:
2007
Tipo del documento:
Artículo
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