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The Effect of Immunized Platelet Transfusion Refractoriness on Allo-HSCT Patients with Malignant Hematological Diseases / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 1923-1928, 2021.
Artículo en Chino | WPRIM | ID: wpr-922225
ABSTRACT
OBJECTIVE@#To investigate the characteristics of platelet antibody in patients with hematological diseases, so as to research the effect of immunized platelet transfusion refractoriness (PTR) on the prognosis of allogeneic hematopoietic stem cell transplantation (allo-HSCT) recepients with malignant hematological diseases patients.@*METHODS@#The clinical data of platelet antibody positive patients tested by Capture-P in the First Affiliated Hospital of Soochow University from July 1, 2014 to July 1, 2019 were retrospectively analyzed, including sex, age, disease, platelet transfusion assessments, CD34@*RESULTS@#In 5 years, 913 (7.28%) hematologic patients with platelet antibody positive were identified, the detection rate of females (513 cases) were higher than males (400 cases). Among the 913 patients, the antibody positive rates of 520 patients with malignant hematological diseases (acute myeloid leukemia, acute lymphoblastic leukemia and myelodysplastic syndrome) showed significantly statistical different (10.27%, 8.01%, and 7.20%) (P<0.01), and the positive rate of the acute myeloid leukemia of those patients was higher than myelodysplastic syndrome patients(α<0.0125). There were 35 cases diagnosed as immunized PTR before allo-HSCT, the platelet increments, 14 h correct count increment, progression-free survival rate and overall survival rate of those patients were significantly lower than those in negative transfusion effective patients (P<0.01), while the percentage of ABO matching was significantly higher (α<0.0125).@*CONCLUSION@#The positive rate of platelet antibody identification is high in females and acute myeloid leukemia patients, and immunized PTR caused by antibody is a risk factor for poor prognosis of allo-HSCT in malignant hematological disease patients.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Estudios Retrospectivos / Transfusión de Plaquetas / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2021 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Síndromes Mielodisplásicos / Leucemia Mieloide Aguda / Estudios Retrospectivos / Transfusión de Plaquetas / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Experimental Hematology Año: 2021 Tipo del documento: Artículo