Research progress of phosphodiesterase inhibitors in inflammatory bowel disease treatment / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 659-665, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-922266
ABSTRACT
Inflammatory bowel disease is a recurrent chronic intestinal inflammatory disease with unknown etiology and no effective treatment. Phosphodiesterase (PDE) regulates a variety of physiological and pathophysiological processes by mediating the hydrolysis of intracellular second messengers cyclic adenosine monophosphate and cyclic guanosine monophosphate. In recent years, a series of researches suggest that PDE inhibitors such as several PDE4 inhibitors, PDE5 inhibitors (sildenafil, tadalafil and vardenafil), PDE3 inhibitors (cilostazol), PDE9 inhibitor (PF-04447943) and PDE3/PDE4 double inhibitor (pumafentrine) have ameliorating effect on experimental colitis in animals. In clinical trials, PDE4 inhibitor apremilast showed more therapeutic advantage than tetomilast. This article reviews the recent research progress of PDE inhibitors in treatment of inflammatory bowel disease.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedades Inflamatorias del Intestino
/
Colitis
/
Inhibidores de Fosfodiesterasa 4
Límite:
Animales
Idioma:
Inglés
Revista:
Journal of Zhejiang University. Medical sciences
Año:
2021
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS