The molecular control of meiotic double-strand break (DSB) formation and its significance in human infertility / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
; (6): 555-561, 2021.
Article
en En
| WPRIM
| ID: wpr-922362
Biblioteca responsable:
WPRO
ABSTRACT
Meiosis is an essential step in gametogenesis which is the key process in sexually reproducing organisms as meiotic aberrations may result in infertility. In meiosis, programmed DNA double-strand break (DSB) formation is one of the fundamental processes that are essential for maintaining homolog interactions and correcting segregation of chromosomes. Although the number and distribution of meiotic DSBs are tightly regulated, still abnormalities in DSB formation are known to cause meiotic arrest and infertility. This review is a detailed account of molecular bases of meiotic DSB formation, its evolutionary conservation, and variations in different species. We further reviewed the mutations of DSB formation genes in association with human infertility and also proposed the future directions and strategies about the study of meiotic DSB formation.
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Índice:
WPRIM
Asunto principal:
Reparación del ADN
/
Roturas del ADN de Doble Cadena
/
Infertilidad
/
Meiosis
Límite:
Humans
Idioma:
En
Revista:
Asian Journal of Andrology
Año:
2021
Tipo del documento:
Article