From bulk, single-cell to spatial RNA sequencing / 国际口腔科学杂志·英文版
International Journal of Oral Science
;
(4): 36-36, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-922464
ABSTRACT
RNA sequencing (RNAseq) can reveal gene fusions, splicing variants, mutations/indels in addition to differential gene expression, thus providing a more complete genetic picture than DNA sequencing. This most widely used technology in genomics tool box has evolved from classic bulk RNA sequencing (RNAseq), popular single cell RNA sequencing (scRNAseq) to newly emerged spatial RNA sequencing (spRNAseq). Bulk RNAseq studies average global gene expression, scRNAseq investigates single cell RNA biology up to 20,000 individual cells simultaneously, while spRNAseq has ability to dissect RNA activities spatially, representing next generation of RNA sequencing. This article highlights these technologies, characteristic features and suitable applications in precision oncology.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Análisis de Secuencia de ARN
/
Medicina de Precisión
/
Secuenciación del Exoma
/
Neoplasias
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
International Journal of Oral Science
Año:
2021
Tipo del documento:
Artículo
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