Reprogramming Glial Cells into Functional Neurons for Neuro-regeneration: Challenges and Promise / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 1625-1636, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-922646
ABSTRACT
The capacity for neurogenesis in the adult mammalian brain is extremely limited and highly restricted to a few regions, which greatly hampers neuronal regeneration and functional restoration after neuronal loss caused by injury or disease. Meanwhile, transplantation of exogenous neuronal stem cells into the brain encounters several serious issues including immune rejection and the risk of tumorigenesis. Recent discoveries of direct reprogramming of endogenous glial cells into functional neurons have provided new opportunities for adult neuro-regeneration. Here, we extensively review the experimental findings of the direct conversion of glial cells to neurons in vitro and in vivo and discuss the remaining issues and challenges related to the glial subtypes and the specificity and efficiency of direct cell-reprograming, as well as the influence of the microenvironment. Although in situ glial cell reprogramming offers great potential for neuronal repair in the injured or diseased brain, it still needs a large amount of research to pave the way to therapeutic application.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neuroglía
/
Reprogramación Celular
/
Neurogénesis
/
Regeneración Nerviosa
/
Neuronas
Límite:
Animales
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2021
Tipo del documento:
Artículo
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