Danshen-Chuanxiongqin Injection attenuates cerebral ischemic stroke by inhibiting neuroinflammation via the TLR2/ TLR4-MyD88-NF-κB Pathway in tMCAO mice / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 772-783, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-922760
ABSTRACT
Danshen-Chuanxiongqin Injection (DCI) is a commonly used traditional Chinese medicine for the treatment of cerebral ischemic stroke in China. However, its underlying mechanisms remain completely understood. The current study was designed to explore the protective mechanisms of DCI against cerebral ischemic stroke through integrating whole-transcriptome sequencing coupled with network pharmacology analysis. First, using a mouse model of cerebral ischemic stroke by transient middle cerebral artery occlusion (tMCAO), we found that DCI (4.10 mL·kg
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Medicamentos Herbarios Chinos
/
Isquemia Encefálica
/
FN-kappa B
/
Accidente Cerebrovascular
/
Infarto de la Arteria Cerebral Media
/
Receptor Toll-Like 2
/
Receptor Toll-Like 4
/
Factor 88 de Diferenciación Mieloide
/
Accidente Cerebrovascular Isquémico
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2021
Tipo del documento:
Artículo
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