Discovery of Eucalyptin C, derived from the fruits of Eucalyptus globulus Labill., as a novel selective PI3Kγ inhibitor for immunosuppressive treatment / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 844-855, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-922767
ABSTRACT
The fruits of Eucalyptus globulus Labill. are known to have a plenty of medicinal properties, such as anti-tumor, anti-inflammatory, and immunosuppressive activity. Our previous study found that the phloroglucinol-sesquiterpene adducts in the fruits of E. globulus were immunosuppressive active constituents, especially Eucalyptin C (EuC). Phosphoinositide 3-kinases-γ (PI3Kγ) plays a pivotal role in T cell mediated excessive immune responses. In this study, EuC was first discovered to be a novel selective PI3Kγ inhibitor with an IC
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Flavonoides
/
Eucalyptus
/
Simulación del Acoplamiento Molecular
/
Frutas
/
Inhibidores de las Quinasa Fosfoinosítidos-3
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2021
Tipo del documento:
Artículo
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