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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3
Acta Pharmaceutica Sinica B ; (6): 3206-3219, 2021.
Artículo en Inglés | WPRIM | ID: wpr-922788
ABSTRACT
The TEA domain (TEAD) family proteins (TEAD1‒4) are essential transcription factors that control cell differentiation and organ size in the Hippo pathway. Although the sequences and structures of TEAD family proteins are highly conserved, each TEAD isoform has unique physiological and pathological functions. Therefore, the development and discovery of subtype selective inhibitors for TEAD protein will provide important chemical probes for the TEAD-related function studies in development and diseases. Here, we identified a novel TEAD1/3 covalent inhibitor (DC-TEADin1072) with biochemical IC

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Inglés Revista: Acta Pharmaceutica Sinica B Año: 2021 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Inglés Revista: Acta Pharmaceutica Sinica B Año: 2021 Tipo del documento: Artículo