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Relationship between Val158Met Polymorphism in Catechol-O-methyltransferase Gene and Depression in Parkinson's Disease / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice ; (12): 753-756, 2018.
Artículo en Chino | WPRIM | ID: wpr-923635
ABSTRACT
@#Objective To explore the relationship between the polymorphism of catechol-O-methyltransferase (COMT) gene Val158Met site and depression in Parkinson's disease. Methods From June, 2016 to December, 2017, a cohort of 268 Chinese patients with Parkinson's disease and 252 age- and gender-matched healthy control subjects were recruited. The patients were divided into depression group (n=116) and non-depression group (n=152) according to Hamilton Depression Scale score. Their blood samples were collected and the polymorphism of Val158Met was carried out using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results No difference was identified in Val158Met polymorphism of genotype (χ2=0.78, P>0.05) and allele (χ2=0.25, P>0.05) among the depression group, the non-depression group and the control group. Conclusion The polymorphism of Val158Met in COMT gene does not contribute to the risk of depression in Parkinson's disease in China.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Rehabilitation Theory and Practice Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Journal of Rehabilitation Theory and Practice Año: 2018 Tipo del documento: Artículo