Role of exercise-induced autophagy in prevention and treatment of nonalcoholic fatty liver disease / 临床肝胆病杂志

ABSTRACT

Nonalcoholic fatty liver disease (NAFLD) is a metabolic disease characterized by chronic liver damage. Epidemiological surveys have shown that the incidence rate of NAFLD is increasing constantly and NAFLD has become a serious threat to human life and health. Studies have shown that autophagy dysregulation is an important pathophysiological mechanism of NAFLD, and exercise, as an important non-pharmacological treatment, can prevent and treat NAFLD by inducing autophagy, but its exact mechanism is still unclear. This article summarizes the theoretical studies and application results related to the association between autophagy and NAFLD, the effect of exercise-induced autophagy on NAFLD, and its potential molecular mechanism, in order to provide a theoretical reference for the prevention and treatment of NAFLD.