Research progress of vascular endothelial growth factor-A and its isoforms in kidney disease / 生理学报
Acta Physiologica Sinica
;
(6): 59-66, 2022.
Artículo
en Chino
| WPRIM
| ID: wpr-927581
ABSTRACT
Vascular endothelial growth factor-A (VEGF-A) is a critical angiogenic factor which is mainly secreted from podocytes and epithelial cells in kidney and plays an important role in renal pathophysiology. In recent years, functions of different isoforms of VEGF-A and the new secretion approach via extracellular vesicles (EVs) have been identified. Thus, further understanding are needed for the role of VEGF-A and its isoforms in renal injury and repair. In this review, we summarized the expression, secretion and regulation of VEGF-A, its biological function, and the role of different isoforms of VEGF-A in the development of different renal diseases. Meanwhile, the research progress of VEGF-A as diagnostic marker and therapeutic target for renal diseases were discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Isoformas de Proteínas
/
Factor A de Crecimiento Endotelial Vascular
/
Riñón
/
Enfermedades Renales
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2022
Tipo del documento:
Artículo
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