Effect of high-intensity interval exercise on depression-related behavior in mice / 生理学报
Acta Physiologica Sinica
;
(6): 165-176, 2022.
Artículo
en Chino
| WPRIM
| ID: wpr-927592
ABSTRACT
This paper was aimed to clarify the effect of high-intensity interval training (HIIT) on depression. Animal running platforms were used to establish HIIT exercise models, depression models were prepared by chronic unpredictable mild stress (CUMS), and depression-related behaviors were detected by behavioral experiments. The results showed that HIIT exercise improved depression-related behavior in CUMS model mice. Western blot and ELISA results showed that in the hippocampus, medial prefrontal cortex (mPFC) and amygdala of the CUMS model mice, glucocorticoid receptor (GR) protein expression was down-regulated, and the content of tumor necrosis factor α (TNF-α) was increased, compared with those in the control group, whereas HIIT exercise could effectively reverse these changes in CUMS model mice. These results suggest that HIIT exercise can exert antidepressant effect, which brings new ideas and means for the clinical treatment of depressive diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estrés Psicológico
/
Conducta Animal
/
Depresión
/
Modelos Animales de Enfermedad
/
Hipocampo
/
Antidepresivos
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2022
Tipo del documento:
Artículo
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