Immunotherapy Based on Tumor Microenvironment in Renal Cell Carcinoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 305-312, 2022.
Artículo
en Chino
| WPRIM
| ID: wpr-927880
ABSTRACT
Renal cell carcinoma (RCC) is a common lethal urological cancer,the distant metastasis of which is the leading cause of death.Although targeted agents have remarkably improved the overall prognosis of RCC patients,nearly all the patients eventually acquire therapeutic resistance.With the advent of immune checkpoint inhibitors,immunotherapy based on tumor microenvironment (TME) has shown a broad scope in clinical application.The deepening understanding of TME leads to the changes of therapeutic strategies for advanced RCC,and the combination of targeted therapy and immunotherapy is exhibiting a promising prospect.Herein,we reviewed the TME characteristics,candidate predictive biomarkers,and possible targets for future development of drugs against RCC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Carcinoma de Células Renales
/
Microambiente Tumoral
/
Inhibidores de Puntos de Control Inmunológico
/
Inmunoterapia
/
Neoplasias Renales
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2022
Tipo del documento:
Artículo
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