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Comparison of effect of interferon-alpha, lamivudine monotherapy and combination therapy in chronic hepatitis B / 대한내과학회지
Korean Journal of Medicine ; : 342-348, 2001.
Artículo en Coreano | WPRIM | ID: wpr-92803
ABSTRACT

BACKGROUND:

Alpha-interferon achieves HBeAg seroconversion in about 30 to 40% of patients with chronic hepatitis B, and recently discovered lamivudine, an oral nucleoside analogue, inhibits hepatitis B virus replication and reduces hepatic necroinflammation in patients with chronic hepatitis B effectively. In this study, we compared the efficacy and safety of alpha-interferon, lamivudine and their combination regimen.

METHODS:

Fourty chronic hepatitis B patients, who were diagnosed through HBV DNA, HBeAg positivity, alanine aminotransferase elevation, and liver biopsy were enrolled in this study. Twelve patients were treated with 500 MU of alpha-interferon subcutaneously 3 times a week for 6 months, 9 patients were treated with 150 mg of lamivudine and alpha-interferon, and 19 patients were treated with 150 lamivudine daily for 6 months.

RESULTS:

After treatment, all of the three groups showed rapid decline in HBV DNA level, but lamivudine group showed more clearance of HBV DNA than interferon group (alpha-interferon 75%, combination group 89%, lamivudine group 100%, respectively) (p=0.04). HBeAg seroconversion rate was 25% for interferon group, 11% for combination group, 26% for lamivudine group, showing no difference between three groups (p=0.705). Mean serum ALT level and rate of ALT normalization during therapy showed no differnece (83% for interferon group, 78% for combination group, 84% for lamivudine group).

CONCLUSION:

It is suggested that the efficacy of combination interferon/lamivudine therapy appears disappointing and further study should be done for appropriate combination or monotherapy of lamivudine for patients with chronic hepatitis B.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Biopsia / ADN / Virus de la Hepatitis B / Interferones / Interferón-alfa / Lamivudine / Hepatitis B Crónica / Alanina Transaminasa / Antígenos e de la Hepatitis B / Hepatitis Crónica Límite: Humanos Idioma: Coreano Revista: Korean Journal of Medicine Año: 2001 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Biopsia / ADN / Virus de la Hepatitis B / Interferones / Interferón-alfa / Lamivudine / Hepatitis B Crónica / Alanina Transaminasa / Antígenos e de la Hepatitis B / Hepatitis Crónica Límite: Humanos Idioma: Coreano Revista: Korean Journal of Medicine Año: 2001 Tipo del documento: Artículo