Secondary metabolites of endophyte fungi Xylaria sp. from Coptis chinensis / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2165-2169, 2022.
Artículo
en Chino
| WPRIM
| ID: wpr-928156
ABSTRACT
Two new polyketides, lasobutone A(1) and lasobutone B(2), along with three known compounds, guignardianone C(3), guignardic acid(4), and 4-hydroxy-17R-methylincisterol(5), were isolated from the endophytic fungi Xylaria sp. by silica gel, MCI, and preparative HPLC, which was separated from the Chinese medicinal material Coptis chinensis and cultivated through solid fermentation with rice. Their structures were elucidated on the basis of spectroscopic methods, such as MS, NMR, IR, UV, and ECD. Compounds 2 and 4 showed inhibitory activities against the nitric oxide(NO) production in the LPS-induced macrophage RAW264.7 with IC_(50) values of 58.7 and 42.5 μmol·L~(-1) respectively, while compound 5 exhibited cytotoxic activities against HT-29 with IC_(50) value of 14.3 μmol·L~(-1).
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Endófitos
/
Policétidos
/
Hongos
/
Coptis chinensis
/
Antineoplásicos
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2022
Tipo del documento:
Artículo
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