Realgar (α-As4S4) Treats Myelodysplastic Syndromes through Reducing DNA Hypermethylation / 中国结合医学杂志
Chinese journal of integrative medicine
;
(12): 281-288, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-928922
ABSTRACT
DNA hypermethylation is an epigenetic modification that plays a critical role in the oncogenesis of myelodysplastic syndromes (MDS). Aberrant DNA methylation represses the transcription of promotors of tumor suppressor genes, inducing gene silencing. Realgar (α-As4S4) is a traditional medicine used for the treatment of various diseases in the ancient time. Realgar was reported to have efficacy for acute promyelocytic leukemia (APL). It has been demonstrated that realgar could efficiently reduce DNA hypermethylation of MDS. This review discusses the mechanisms of realgar on inhibiting DNA hypermethylation of MDS, as well as the species and metabolisms of arsenic in vivo.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Arsenicales
/
Sulfuros
/
Síndromes Mielodisplásicos
/
ADN
/
Metilación de ADN
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese journal of integrative medicine
Año:
2022
Tipo del documento:
Artículo
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