Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 235-248, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-929091
ABSTRACT
Recent studies have revealed great functional and structural heterogeneity in the ribbon-type synapses at the basolateral pole of the isopotential inner hair cell (IHC). This feature is believed to be critical for audition over a wide dynamic range, but whether the spatial gradient of ribbon morphology is fine-tuned in each IHC and how the mitochondrial network is organized to meet local energy demands of synaptic transmission remain unclear. By means of three-dimensional electron microscopy and artificial intelligence-based algorithms, we demonstrated the cell-wide structural quantification of ribbons and mitochondria in mature mid-cochlear IHCs of mice. We found that adjacent IHCs in staggered pairs differ substantially in cell body shape and ribbon morphology gradient as well as mitochondrial organization. Moreover, our analysis argues for a location-specific arrangement of correlated ribbon and mitochondrial function at the basolateral IHC pole.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sinapsis
/
Inteligencia Artificial
/
Cóclea
/
Células Ciliadas Auditivas Internas
/
Mitocondrias
Límite:
Animales
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2022
Tipo del documento:
Artículo
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