Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 403-416, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-929123
ABSTRACT
Spinal cord stimulation (SCS)-induced analgesia was characterized, and its underlying mechanisms were examined in a spared nerve injury model of neuropathic pain in rats. The analgesic effect of SCS with moderate mechanical hypersensitivity was increased with increasing stimulation intensity between the 20% and 80% motor thresholds. Various frequencies (2, 15, 50, 100, 10000 Hz, and 2/100 Hz dense-dispersed) of SCS were similarly effective. SCS-induced analgesia was maintained without tolerance within 24 h of continuous stimulation. SCS at 2 Hz significantly increased methionine enkephalin content in the cerebrospinal fluid. The analgesic effect of 2 Hz was abolished by μ or κ opioid receptor antagonist. The effect of 100 Hz was prevented by a κ antagonist, and that of 10 kHz was blocked by any of the μ, δ, or κ receptor antagonists, suggesting that the analgesic effect of SCS at different frequencies is mediated by different endorphins and opioid receptors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Médula Espinal
/
Receptores Opioides
/
Receptores Opioides kappa
/
Péptidos Opioides
/
Estimulación de la Médula Espinal
/
Analgésicos
/
Antagonistas de Narcóticos
/
Neuralgia
Límite:
Animales
Idioma:
Inglés
Revista:
Neuroscience Bulletin
Año:
2022
Tipo del documento:
Artículo
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