Nuclear cGAS: sequestration and beyond
Protein & Cell
;
(12): 90-101, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-929171
ABSTRACT
The cyclic GMP-AMP (cGAMP) synthase (cGAS) has been identified as a cytosolic double stranded DNA sensor that plays a pivotal role in the type I interferon and inflammation responses via the STING-dependent signaling pathway. In the past several years, a growing body of evidence has revealed that cGAS is also localized in the nucleus where it is associated with distinct nuclear substructures such as nucleosomes, DNA replication forks, the double-stranded breaks, and centromeres, suggesting that cGAS may have other functions in addition to its role in DNA sensing. However, while the innate immune function of cGAS is well established, the non-canonical nuclear function of cGAS remains poorly understood. Here, we review our current understanding of the complex nature of nuclear cGAS and point to open questions on the novel roles and the mechanisms of action of this protein as a key regulator of cell nuclear function, beyond its well-established role in dsDNA sensing and innate immune response.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transducción de Señal
/
Núcleo Celular
/
Inmunidad Innata
/
Nucleotidiltransferasas
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2022
Tipo del documento:
Artículo
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