Biosensor-based assay of exosome biomarker for early diagnosis of cancer / 医学前沿
Frontiers of Medicine
;
(4): 157-175, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-929191
ABSTRACT
Cancer imposes a severe threat to people's health and lives, thus pressing a huge medical and economic burden on individuals and communities. Therefore, early diagnosis of cancer is indispensable in the timely prevention and effective treatment for patients. Exosome has recently become an attractive cancer biomarker in noninvasive early diagnosis because of the unique physiology and pathology functions, which reflects remarkable information regarding the cancer microenvironment, and plays an important role in the occurrence and evolution of cancer. Meanwhile, biosensors have gained great attention for the detection of exosomes due to their superior properties, such as convenient operation, real-time readout, high sensitivity, and remarkable specificity, suggesting promising biomedical applications in the early diagnosis of cancer. In this review, the latest advances of biosensors regarding the assay of exosomes were summarized, and the superiorities of exosomes as markers for the early diagnosis of cancer were evaluated. Moreover, the recent challenges and further opportunities of developing effective biosensors for the early diagnosis of cancer were discussed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Técnicas Biosensibles
/
Biomarcadores de Tumor
/
Exosomas
/
Detección Precoz del Cáncer
/
Microambiente Tumoral
/
Neoplasias
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2022
Tipo del documento:
Artículo
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