Bioactive neolignans and lignans from the roots of Paeonia lactiflora / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 210-214, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-929253
ABSTRACT
Two new neolignans and one new lignan (1-3) were obtained from the roots of Paeonia lactiflora. Their structures were unambiguously elucidated based on extensive spectroscopic analysis, single-crystal X-ray crystallography, and the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 was a racemic mixture and successfully resolved into the anticipated enantiomers via chiral-phase HPLC. Compound 3 demonstrated moderate inhibitory activity against human carboxylesterase 2A1 (hCES2A1) with an IC50 value of 7.28 ± 0.94 μmol·-1.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estereoisomerismo
/
Cromatografía Líquida de Alta Presión
/
Lignanos
/
Raíces de Plantas
/
Paeonia
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2022
Tipo del documento:
Artículo
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