The relationship between sepsis and hemophagocytic lymphohistiocytosis in children: similarities and differences / 中国小儿急救医学

ABSTRACT

Pediatric sepsis is caused by the imbalance of the host immune response caused by severe infection, while hemophagocytic lymphohistiocytosis(HLH) is an excessive immune activation syndrome caused by natural killer cell/CD8 + T lymphocyte dysfunction.The two diseases can lead to life-threatening multiple organ dysfunction, and their clinical features are similar but different.In addition, sepsis may progress for HLH and HLH can also be secondary to sepsis.This review summarized the similarities and differences between sepsis and HLH in order to provide clinicians with a deeper understanding.