Comparative study of serum levels of albumin and hs-CRP in hemodialysis patients according to protein intake levels / 한국영양학회지
Journal of Nutrition and Health
;
: 521-530, 2013.
Artículo
en Coreano
| WPRIM
| ID: wpr-93176
ABSTRACT
Protein-energy malnutrition, PEM, and increased hs-CRP level are considered to be associated with increased risk of cardiovascular disease (CVD) in hemodialysis (HD) patients. This is commonly referred to as the vicious circle of malnutrition-inflammation-atherosclerosis cardiovascular disease (MIA syndrome) in chronic kidney disease (CKD). Low protein intake can decrease the serum level of albumin and increase inflammational markers; further, both low serum albumin and high hs-CRP are independent risk factors for all-cause mortality in HD patients. The aim of this study is comparing the serum levels of albumin and hs-CRP in HD patients according to the protein intake levels. The total number of subjects was 60 hemodialysis patients; they were grouped by dietary protein intake low protein intake group (LPI, protein intake or = 1.0 g/kg IBW, 12 men and 18 women). Blood biochemical parameters, nutrient intake, and dietary behaviors were compared between the LPI and API groups. The LPI group showed a significantly lower serum level of albumin and higher serum level of hs-CRP than the API group (p < 0.05). The LPI group showed a significantly lower intake of most nutrients than the API group (p < 0.05). Index of Nutritional Quality of most nutrients of the LPI and API groups were lower than 1.0. Dietary protein intake was positively correlated with the serum level of albumin (r = 0.306, p < 0.05) and negatively correlated with the serum level of hs-CRP (r = -0.435, p < 0.01). The serum level of hs-CRP was negatively correlated with that of albumin (r = -0.393, p < 0.01). According to these result, serum albumin and hs-CRP in HD patients were influenced by the protein intake levels. To prevent MIA syndrome, it is necessary to improve nutritional status, especially in protein and energy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Albúmina Sérica
/
Proteínas en la Dieta
/
Enfermedades Cardiovasculares
/
Estado Nutricional
/
Factores de Riesgo
/
Mortalidad
/
Diálisis Renal
/
Desnutrición Proteico-Calórica
/
Insuficiencia Renal Crónica
/
Valor Nutritivo
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Nutrition and Health
Año:
2013
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS