Research progress of nicorandil on reperfusion effect of acute ST segment elevation myocardial infarction / 中国医师杂志

ABSTRACT

Nicorandil is a new vasodilator, which has the dual effects of nitrate like ester and ATP sensitive potassium channel (KATP channel) opening. Intracoronary injection of nicorandil can expand the coronary artery, protect the coronary microcirculation, and play an anti-inflammatory role, inhibit microthrombosis, increase myocardial perfusion and reduce the incidence of no reflow by acting on a variety of signal pathways; It can also reduce the infarct area and improve cardiac function; Through a variety of cell membrane enzyme signal pathways, it can significantly increase the outflow of potassium ions in cells, cause cell membrane hyperpolarization, inhibit the flow of calcium ions into cells and intracellular calcium overload, reduce the occurrence of abnormal reperfusion rhythm and reperfusion injury. Therefore, it has a good myocardial protective effect on patients with acute myocardial infarction.