Autophagy and bacterial infectious diseases
Experimental & Molecular Medicine
; : 99-108, 2012.
Article
en En
| WPRIM
| ID: wpr-93420
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WPRO
ABSTRACT
Autophagy is a housekeeping process that maintains cellular homeostasis through recycling of nutrients and degradation of damaged or aged cytoplasmic constituents. Over the past several years, accumulating evidence has suggested that autophagy can function as an intracellular innate defense pathway in response to infection with a variety of bacteria and viruses. Autophagy plays a role as a specialized immunologic effector and regulates innate immunity to exert antimicrobial defense mechanisms. Numerous bacterial pathogens have developed the ability to invade host cells or to subvert host autophagy to establish a persistent infection. In this review, we have summarized the recent advances in our understanding of the interaction between antibacterial autophagy (xenophagy) and different bacterial pathogens.
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Asunto principal:
Autofagia
/
Infecciones Bacterianas
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Especies Reactivas de Oxígeno
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Inmunidad Innata
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Experimental & Molecular Medicine
Año:
2012
Tipo del documento:
Article