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Progress in the application of three-dimensional cell culture model in toxicity tests of xenobiotic / 中华预防医学杂志
Chinese Journal of Preventive Medicine ; (12): 20-24, 2022.
Artículo en Chino | WPRIM | ID: wpr-935244
ABSTRACT
In the process of xenobiotic toxicity prediction and risk assessment, in vitro cell culture models possess high practical application value. With the rapid development of biological technologies such as three-dimensional (3D) bio-printing, organoid culture and organ-on-a-chip systems, in vitro cell culture models have made great progress. Sharing the similarities in structure, function and the physiological environment with tissues or organs in vivo, hazard identification and dose-response analysis based on 3D cell culture models provide access to more accurate toxicity data as a theoretical basis for risk assessment and risk management of chemicals. This review summarizes the establishment of three typical 3D cell culture models, i.e., human cell line-based co-culture model, 3D-printed scaffold-based cell culture model and organoids, and their application in toxicity tests of xenobiotics.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Xenobióticos / Línea Celular / Pruebas de Toxicidad / Técnicas de Cultivo de Célula / Técnicas de Cultivo Tridimensional de Células Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Preventive Medicine Año: 2022 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Xenobióticos / Línea Celular / Pruebas de Toxicidad / Técnicas de Cultivo de Célula / Técnicas de Cultivo Tridimensional de Células Tipo de estudio: Estudio pronóstico Límite: Humanos Idioma: Chino Revista: Chinese Journal of Preventive Medicine Año: 2022 Tipo del documento: Artículo