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Recent progress of novel circular RNA regulating chemotherapy resistance in glioma / 中国药房
China Pharmacy ; (12): 1916-1920, 2022.
Artículo en Chino | WPRIM | ID: wpr-936503
ABSTRACT
Glioma is a malignant tumor with extremely high rates of recurrence. Clinically ,with the prolongation of the use of chemotherapy drugs ,the drug resistance of glioma cells to chemotherapy drugs is also increasing ,which eventually leads to poor prognosis and shortens overall survival time of patients. It is well known that the development of drug resistance involves multiple mechanisms,including drug transport metabolismapoptosisDNA damage repair ,autophagy,variation of cancer stem cells and epithelial mesenchymal transition. Abnormal expression of circular RNAcircRNA),a novel RNA molecule with unique stability and tissue specificity ,has been shown by more and more evidence to play a crucial regulatory role in the development of drug resistance in glioma. This paper systematically reviews the mechanism of multiple drug resistance in glioma ,and focuses on the role and molecular mechanism of circRNA regulating temozolomide-resistance in glioma. At the same time ,the potential function of circRNA as a new therapeutic target is prospected ,in order to provide an objective theoretical basis for the development of new therapeutic methods.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2022 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: China Pharmacy Año: 2022 Tipo del documento: Artículo