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The Effect of alpha-Melanocyte Stimulating Hormone on Renal Ischemia Reperfusion Injury / 대한이식학회지
The Journal of the Korean Society for Transplantation ; : 49-54, 2006.
Artículo en Coreano | WPRIM | ID: wpr-93713
ABSTRACT

PURPOSE:

In ischemia-reperfusion induced renal injuries, cytokines, chemoattractant chemokines, adhesion molecules and nitric oxide play an important role. alpha-Melanocyte stimulating hormone (alpha-MSH) is a potent anti-inflammatory cytokine so the therapeutic effect of alpha-MSH on an ischemia-reperfusion induced acute renal failure is to be evaluated.

METHODS:

40 male Spraque-Dawley rats were prepared for the experiment, they were classified into three classes (Sham, ischemic control and alpha-MSH injection). Both renal pedicles were clamped for 45 minutes. alpha-MSH (50 microgram) was injected intravenously three times, immediately before ischemia and reperfusion and 18 hour after reperfusion. Serum creatinine and histologic changes were analyzed between groups (Sham (n=6), ischemic control group (n=15), and alpha-MSH group (n=19)).

RESULTS:

Serum creatinine level decreased significantly at 24 hours after reperfusion in alpha-MSH treated animals (SCr24 0.78+/-0.23 mg/dL, 4.21+/-1.14 mg/dL, 3.01+/-1.19 mg/dL, repectively (P=0.008)), especially serum creatinine level at 48 hours after reperfusion much more dicreased in alpha-MSH group (SCr48 0.67+/-0.16 mg/dL, 4.21+/-2.03 mg/dL, 1.15+/-1.11 mg/dL, repectively (P=0.004)). Tubular neccrosis and neutrophil infiltration decreased signigicantly in alpha-MSH treated group (P=0.001). Mortality was noted 33.3% only at ischemic conrol group.

CONCLUSION:

we demonstrate the fact that alpha-MSH has protective role on ischemic renal injury and improves survival rates.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Alfa-MSH / Reperfusión / Daño por Reperfusión / Tasa de Supervivencia / Mortalidad / Citocinas / Quimiocinas / Creatinina / Infiltración Neutrófila / Lesión Renal Aguda Tipo de estudio: Estudio pronóstico Límite: Animales / Humanos / Masculino Idioma: Coreano Revista: The Journal of the Korean Society for Transplantation Año: 2006 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Alfa-MSH / Reperfusión / Daño por Reperfusión / Tasa de Supervivencia / Mortalidad / Citocinas / Quimiocinas / Creatinina / Infiltración Neutrófila / Lesión Renal Aguda Tipo de estudio: Estudio pronóstico Límite: Animales / Humanos / Masculino Idioma: Coreano Revista: The Journal of the Korean Society for Transplantation Año: 2006 Tipo del documento: Artículo