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Treatment of CD19-Positive Mixed Phenotype Acute Leukemia with Blinatumomab / 대한내과학회지
Korean Journal of Medicine ; : 60-63, 2022.
Artículo en Coreano | WPRIM | ID: wpr-938676
ABSTRACT
Mixed phenotype acute leukemia (MPAL) encompasses a rare group of acute leukemia with blasts expressing markers specific to several lineages, which accounts for 2-5% of all newly diagnosed cases of acute leukemia. At present, patients with MPAL are treated with acute lymphoblastic leukemia (ALL)-directed chemotherapy. However, the prognosis of MPAL, especially in cases of relapsed/refractory (R/R) disease, remains poor. Blinatumomab, a bispecific T cell-engaging antibody, has shown encouraging outcomes in R/R B cell ALL positive for CD19. Here, we report a patient with CD19+ MPAL who achieved complete remission after treatment with blinatumomab, which may be a therapeutic option for patients with relapsed CD19+ MPAL. To our knowledge, this is the first case report of MPAL treated with blinatumomab in Korea.
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Coreano Revista: Korean Journal of Medicine Año: 2022 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Coreano Revista: Korean Journal of Medicine Año: 2022 Tipo del documento: Artículo