Non-alcoholic fatty liver diseases: update on the challenge of diagnosis and treatment
Clinical and Molecular Hepatology
;
: 327-335, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-93972
ABSTRACT
The prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to be 25-30% of the population, and is the most common cause of elevated liver enzymes in Korea. NAFLD is a "hot potato" for pharmaceutical companies. Many clinical trials are underway to develop a first-in-class drug to treat NAFLD. However, there are several challenging issues regarding the diagnosis of NAFLD. Currently, liver biopsy is the gold standard method for the diagnosis of NAFLD and steatohepatitis. Ideally, globally recognized standards for histological diagnosis and methods to optimize observer agreement on biopsy interpretation should be developed. Liver biopsy is the best method rather than a perfect one. Recently, multi-parametric magnetic resonance imagery can estimate the amount of intrahepatic fat successfully and is widely used in clinical trials. But no diagnostic method can discriminate between steatohepatitis and simple steatosis. The other unresolved issue in regard to NAFLD is the absence of satisfactory treatment options. Vitamin E and obeticholic acid have shown protective effects in randomized controlled trials, but this drug has not been approved for use in Korea. This study will provide a description of diagnostic methods and treatments that are currently recommended for NAFLD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Vitamina E
/
Fibrosis
/
Imagen por Resonancia Magnética
/
Biomarcadores
/
Tomografía Computarizada por Rayos X
/
Ácido Quenodesoxicólico
/
Ensayos Clínicos como Asunto
/
Ultrasonografía
/
Hígado Graso
/
Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
/
Guía de Práctica Clínica
Límite:
Humanos
Idioma:
Inglés
Revista:
Clinical and Molecular Hepatology
Año:
2016
Tipo del documento:
Artículo
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