Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells
Protein & Cell
;
(12): 476-489, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-939867
ABSTRACT
Cell therapy approaches that employ engineered mammalian cells for on-demand production of therapeutic agents in the patient's body are moving beyond proof-of-concept in translational medicine. The therapeutic cells can be customized to sense user-defined signals, process them, and respond in a programmable and predictable way. In this paper, we introduce the available tools and strategies employed to design therapeutic cells. Then, various approaches to control cell behaviors, including open-loop and closed-loop systems, are discussed. We also highlight therapeutic applications of engineered cells for early diagnosis and treatment of various diseases in the clinic and in experimental disease models. Finally, we consider emerging technologies such as digital devices and their potential for incorporation into future cell-based therapies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ingeniería Genética
/
Redes Reguladoras de Genes
/
Biología Sintética
/
Ingeniería Celular
/
Mamíferos
Tipo de estudio:
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2022
Tipo del documento:
Artículo
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