Outcome and Prognostic Factors of Childhood Diffuse Brainstem Glioma / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 109-113, 2005.
Artículo
en Inglés
| WPRIM
| ID: wpr-94154
ABSTRACT
PURPOSE:
The outcome and prognostic factors of brainstem glioma were evaluated following radiotherapy methods. MATERIALS ANDMETHODS:
Between 1986 and 2001, 45 childhood patients with diffuse brainstem glioma were treated. There were 26 boys and 19 girls, with a median age of 7 years (range 3~18). The histopathological diagnoses were confirmed in 13 patients, which revealed a low-grade glioma in four patients, and high-grade glioma in the other nine. Before 1993, radiation therapy using a regime of 1.8 to 2.0 Gy once a day was performed in 16 cases; thereafter, a regimes of 1.1 or 1.5 Gy twice a day was given in 15 and 14 cases, respectively. Nine patients were treated with adjuvant chemotherapy. The response to the treatment was evaluated by the MRI findings 4 weeks after radiotherapy.RESULTS:
After radiotherapy, the neurological deficit improved in 42 of the 45 patients (93%). The MRI responses were as follows; partial response 22/39 (56%), minimal to no response in 16/39 (41%) and tumor progression in 1/39 (3%). The median time to disease progression was 7 months, and the median survival was 12 months; the overall survival rate at 1 year was 41%. There was no significant prognostic factor for overall survival. The progression-free survival was influenced by the tumor histology (low grade vs. high grade, p=0.05) in those patients whose pathology was confirmed.CONCLUSION:
The radiation therapy fractionation schedule did not influence the survival. Low grade histology was a possible favorable prognostic factor of progression-free survival in pediatric brainstem glioma patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Citas y Horarios
/
Radioterapia
/
Tronco Encefálico
/
Imagen por Resonancia Magnética
/
Tasa de Supervivencia
/
Quimioterapia Adyuvante
/
Supervivencia sin Enfermedad
/
Progresión de la Enfermedad
/
Diagnóstico
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2005
Tipo del documento:
Artículo
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