Gum resin extract of Boswellia serrata attenuates lipopolysaccharide-induced inflammation and oxidative damage in hepatic and renal tissues of rats
Asian Pacific Journal of Tropical Medicine
;
(12): 20-25, 2022.
Artículo
en Chino
| WPRIM
| ID: wpr-941600
ABSTRACT
Objective:
To explore the effect of ethyl acetate gum resin extract of Boswellia serrata on lipopolysaccharide (LPS) induced inflammation and oxidative damage in hepatic and renal tissues of rats.Methods:
The rats were divided into four groups control, LPS, LPS+Boswellia serrata extracts (100 mg/kg and 200 mg/kg). LPS (1 mg/kg) and the extract (100 and 200 mg/kg, 30 min before LPS) were administered intraperitoneally for 3 weeks. The levels of liver enzymes, albumin, total protein, creatinine, blood urea nitrogen (BUN), interleukin (IL)-6, malondialdehyde (MDA), and total thiol groups and superoxide dismutase (SOD) and catalase (CAT) activities were measured.Results:
The levels of liver enzymes, creatinine, and BUN, IL-6, MDA in the LPS group were markedly increased (P<0.001) while albumin, total protein, and total thiol concentration, as well as SOD and CAT activities, were decreased compared with the control group (P<0.05 or 0.01). Boswellia serrata extracts diminished the levels of liver enzymes, creatinine, BUN, IL-6, and MDA (P<0.01 and P<0.001), and elevated the concentration of total protein and total thiol and SOD and CAT activities (P<0.05 or 0.01).Conclusions:
The ethyl acetate gum resin extract of Boswellia serrata reduces LPS-induced inflammatory reactions and oxidative damage, thus ameliorating hepatic and renal function.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2022
Tipo del documento:
Artículo
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