Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A / 中国药房
China Pharmacy
;
(12): 2285-2289, 2022.
Artículo
en Chino
| WPRIM
| ID: wpr-943074
ABSTRACT
Cyclosporine A is widely used in organ transplantation and autoimmune diseases . Due to the obvious differences in metabolism between individuals ,the dosage should be adjusted according to the patient ’s blood concentration during clinical use . But the blood concentration does not reflect accurately its clinical prognosis . This article focuses on the four laboratory examination indexes following aspects :the cyclosporine A concentration of peripheral blood mononuclear cells ,calcineurin activity ,T cell function and metabolite concentration of cyclosporine A . The relationship between them and the pharmacokinetics of cyclosporine and clinical prognosis were reviewed . It’s found that the above indicators have a certain predictive effect on the clinical prognosis of patients receiving cyclosporine A ,which can make up for the insufficiency of blood drug concentration monitoring ,and the clinical practicability needs to be further improved .
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
China Pharmacy
Año:
2022
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS