Clinicopathologic Manifestations of 36 Korean Patients with Acute Generalized Exanthematous Pustulosis: A Case Series and Review of the Literature
Annals of Dermatology
;
: 163-169, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-94328
ABSTRACT
BACKGROUND:
Acute generalized exanthematous pustulosis (AGEP) is a rare and severe subtype of drug eruption, characterized by acute, extensive, non-follicular, sterile pustules on an erythematous background, accompanied by fever and leukocytosis.OBJECTIVE:
The purpose of this study was to characterize AGEP in Korean patients in terms of clinical, laboratory, and pathologic findings.METHODS:
Thirty-six patients (MF=1719) with AGEP were identified from an extensive review of medical records over a 15 year period. All patient cases were confirmed by biopsy and fulfilled the diagnostic criteria.RESULTS:
The patient ages ranged from 4~80 years (37.6+/-19.4). The incubation period was 1~23 days. The duration of disease was 5~14 days. Neutrophilia (36/36), high CRP (14/36), and eosinophilia (30/36) were common laboratory findings. A history of drug administration existed in 23 of 36 patients; herbal medications, lacquers and radiocontrast media were the unique causative drugs. Spongioform subcorneal or intraepidermal pustules in the epidermis was observed in all patients. Thirty-six patients were subdivided into 2 groups group A (n=23) was strongly associated with known agents; and group B (n=13) had no identified causative agents. There was no significant difference between the 2 groups.CONCLUSION:
Our results demonstrate the characteristic features of AGEP in Korean patients as follows lower identification of causative agents; herbal medications, lacquers, and radiocontrast media were the main causative agents; and no significant differences existed between the 2 groups.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Biopsia
/
Registros Médicos
/
Erupciones por Medicamentos
/
Medios de Contraste
/
Eosinofilia
/
Epidermis
/
Pustulosis Exantematosa Generalizada Aguda
/
Fiebre
/
Laca
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of Dermatology
Año:
2010
Tipo del documento:
Artículo
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