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Clinical Features and Treatment Outcomes of Upper Gastrointestinal Bleeding in Patients with Cirrhosis
Journal of Korean Medical Science ; : 635-643, 2008.
Artículo en Inglés | WPRIM | ID: wpr-9475
ABSTRACT
With recent progress in treatment modalities, mortality from upper gastrointestinal (UGI) bleeding has decreased appreciably. The aim of this study was to establish how UGI bleeds are managed in Korean patients with cirrhosis and to evaluate treatment outcomes. A total of 479 episodes of acute UGI bleeding in 464 patients with cirrhosis were included during a six-month period at nine tertiary medical centers. Treatment outcomes were assessed by failure to control bleeding, rebleeding and mortality. The source of bleeding was esophagogastric varices in 77.7% of patients, nonvariceal lesions in 15.9%, and undefined in 6.5%. For control of bleeding, endoscopic and pharmacologic treatments were used in 74.7% and 81.9% of patients, respectively. Variceal ligation was a major technique for endoscopic treatment (90%), and terlipressin and somatostatin were the main pharmacologic agents used (96.4%). Initial hemostasis was achieved in 86.8% of cases, but rebleeding occurred in 3.8% and 16.8% of cases within five days and six weeks of hemorrhage, respectively. Five-day and six-week mortality were 11.3% and 25.9%, respectively. Survival of patients with variceal bleeding seems to be remarkably improved than previous reports, which may suggest the advances in hemostatic methods for control of variceal hemorrhage..
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lipresina / Estudios de Cohortes / Técnicas Hemostáticas / Resultado del Tratamiento / Hemorragia Gastrointestinal / Infecciones / Cirrosis Hepática Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2008 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lipresina / Estudios de Cohortes / Técnicas Hemostáticas / Resultado del Tratamiento / Hemorragia Gastrointestinal / Infecciones / Cirrosis Hepática Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Adulto / Anciano / Femenino / Humanos / Masculino Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2008 Tipo del documento: Artículo