In vivo antiplasmodial and in vitro antioxidant properties of stem bark extracts of Haematostaphis barteri
Asian Pacific Journal of Tropical Biomedicine
;
(12): 446-450, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-950928
ABSTRACT
Objective:
To evaluate the antimalarial and antioxidant properties of stem bark extracts of Haematostaphis barteri (H. barteri).Methods:
The prophylactic activity of the plant was performed by dosing mice with sulfadoxine-pyrimethamine (1.2 mg/kg), aqueous extract (30, 100, 300 mg/kg) and dichloromethane/methanol (D/M) (30, 100, 300 mg/kg) extracts of H. barteri for 3 days. On the 4th day, the mice were inoculated with Plasmodium berghei. The parasite density was estimated for each mouse 72 h post-parasite inoculation. The curative activity of the plant was also performed by inoculating mice with Plasmodium berghei. Three days later, they were treated with artemether-lumefantrine (4 mg/kg), aqueous and D/M extracts of H. barteri stembark for 5 days. The in vitro antioxidant property of the aqueous extractwas determined by using the reducing power, nitric oxide and total antioxidant capacity assays.Results:
The aqueous extract exerted significant (P < 0.05) curative and prophylactic antimalarial activities. The D/M extract exhibited significant curative (P < 0.05) but not prophylactic antiplasmodial effect. The aqueous extract exhibited in vitro antioxidant property with IC
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Asian Pacific Journal of Tropical Biomedicine
Año:
2015
Tipo del documento:
Artículo
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