Effects of arteannuin B, arteannuic acid and scopoletin on pharmacokinetics of artemisinin in mice
Asian Pacific Journal of Tropical Medicine
; (12): 677-681, 2016.
Article
en Zh
| WPRIM
| ID: wpr-951372
Biblioteca responsable:
WPRO
ABSTRACT
Objective To explore the effects of arteannuin B, arteannuic acid and scopoletin on the pharmacokinetics of artemisinin in mice. Methods Artemisinin and a combination of artemisinin, arteannuin B, arteannuic acid and scopoletin were administered together to mice via oral administration. Blood samples were collected at different time intervals and pretreated by liquid–liquid extraction. The contents of four compounds in mouse plasma were determined by a validated HPLC-MS/MS method. Results Compared to single artemisinin group, the C
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WPRIM
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Zh
Revista:
Asian Pacific Journal of Tropical Medicine
Año:
2016
Tipo del documento:
Article