Chronopharmacology in Clinical Medicine / 수면정신생리
Sleep Medicine and Psychophysiology
;
: 67-72, 2004.
Artículo
en Coreano
| WPRIM
| ID: wpr-95159
ABSTRACT
Circadian rhythm is a global phenomenon, the control mechanisms of which are manifested at every level of biological organization, from genes and intracellular mechanisms to networks of cell populations, and to all central neuronal systems at the organismic level. In pharmacotherapy, the pharmacokinetic parameters such as drug absorption and distribution, drug metabolism, and renal elimination show diurnal variations. The symptoms and signs in diseases like asthma, myocardiac infarction, angina pectoris, hypertension and stroke also show diurnal fluctuations. These observations require drug treatment considering the circadian rhythm of body function and disease. Circadian time has to be taken into account as an important variable influencing a drug's pharmacokinetics and/or its effects or side effects in clinical practice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Asma
/
Farmacocinética
/
Medicina Clínica
/
Ritmo Circadiano
/
Accidente Cerebrovascular
/
Quimioterapia
/
Absorción
/
Hipertensión
/
Infarto
/
Angina de Pecho
Idioma:
Coreano
Revista:
Sleep Medicine and Psychophysiology
Año:
2004
Tipo del documento:
Artículo
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