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Impact of antibacterial drugs on human serum paraoxonase-1 (hPON1) activity: An in vitro study
Asian Pacific Journal of Tropical Biomedicine ; (12): 603-609, 2014.
Artículo en Chino | WPRIM | ID: wpr-951822
ABSTRACT

Objective:

To investigate the in vitro effects of the antibacterial drugs, meropenem trihydrate, piperacillin sodium, and cefoperazone sodium, on the activity of human serum paraoxonase (hPON1).

Methods:

hPON1 was purified from human serum using simple chromatographic methods, including DEAE-Sephadex anion exchange and Sephadex G-200 gel filtration chromatography.

Results:

The three antibacterial drugs decreased in vitro hPON1 activity. Inhibition mechanisms meropenem trihydrate was noncompetitive while piperacillin sodium and cefoperazone sodium were competitive.

Conclusions:

Our results showed that antibacterial drugs significantly inhibit hPON1 activity, both in vitro, with rank order meropenem trihydrate piperacillin sodium cefoperazone sodium in vitro.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Asian Pacific Journal of Tropical Biomedicine Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Asian Pacific Journal of Tropical Biomedicine Año: 2014 Tipo del documento: Artículo