Illuminating Neural Circuits in Alzheimer’s Disease / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 1203-1217, 2021.
Article
en Zh
| WPRIM
| ID: wpr-951965
Biblioteca responsable:
WPRO
ABSTRACT
Alzheimer’s disease (AD) is the most common neurodegenerative disorder and there is currently no cure. Neural circuit dysfunction is the fundamental mechanism underlying the learning and memory deficits in patients with AD. Therefore, it is important to understand the structural features and mechanisms underlying the deregulated circuits during AD progression, by which new tools for intervention can be developed. Here, we briefly summarize the most recently established cutting-edge experimental approaches and key techniques that enable neural circuit tracing and manipulation of their activity. We also discuss the advantages and limitations of these approaches. Finally, we review the applications of these techniques in the discovery of circuit mechanisms underlying β-amyloid and tau pathologies during AD progression, and as well as the strategies for targeted AD treatments.
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1
Índice:
WPRIM
Idioma:
Zh
Revista:
Neuroscience Bulletin
Año:
2021
Tipo del documento:
Article