Wiring the Brain by Clustered Protocadherin Neural Codes / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 117-131, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-952021
ABSTRACT
There are more than a thousand trillion specific synaptic connections in the human brain and over a million new specific connections are formed every second during the early years of life. The assembly of these staggeringly complex neuronal circuits requires specific cell-surface molecular tags to endow each neuron with a unique identity code to discriminate self from non-self. The clustered protocadherin (Pcdh) genes, which encode a tremendous diversity of cell-surface assemblies, are candidates for neuronal identity tags. We describe the adaptive evolution, genomic structure, and regulation of expression of the clustered Pcdhs. We specifically focus on the emerging 3-D architectural and biophysical mechanisms that generate an enormous number of diverse cell-surface Pcdhs as neural codes in the brain.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Neuroscience Bulletin
Año:
2021
Tipo del documento:
Artículo
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