Advances in the malnutrition of pediatric chronic cholestatic disease / 国际儿科学杂志

ABSTRACT

Despite recent advances in pediatric chronic cholestatic diseases, the causes and effective therapies remain elusive, and many patients progress to liver failure and need liver transplantation.Malnutrition is a common complication in these patients and is a well-recognized, tremendous challenge for the clinician.The malnutrition and failure to thrive are associated with increased risks of morbidity and mortality, and they also affect the outcomes of liver transplantation, including long-term survival.Malnutrition in children with chronic cholestatic disease is multifactorial and with multiple potential nutritional deficiencies.Supplemental feeding, including medium-chain triglycerides, essential fatty acids, branched-chain amino acids.In order to improve the life expectancy and quality of life of children with chronic liver disease, this paper reviews ways to address the nutritional needs for specific cause of malnutrition in children.