The formula and medication rules of Chinese patent medicines for jaundice based on data mining / 国际中医中药杂志

ABSTRACT

Objective:To analyze the formula and medication rules based on the Chinese patent medicines database for treating jaundice, so as to provide reference for the treatment of jaundice.Methods:By using descriptive statistics and data mining methods to analyze the current condition of Chinese patent medicines treating jaundice, Chinese medicines that are frequently appeared and the Chinese medicine paris as well as the combination of mediicnes, and then by using complex network clustering and topology parameter analysis to screen the potential formulations and core Chinese medicines.Results:Seventy-nine Chinese patent medicines with the function of heat-clearing and detoxification were obtained, heat-clearing and removing dampness, and removing jaundice. A total of 233 Chinese medicines are involved, and the most frequently used are Artemisiae Scopariae Herba, Glycyrrhizae Radix et Rhizoma, Bupleuri Radix, Gardeniae Fructus, Scutellariae Radix, etc. The Chinese medicine pairs with high association rule support were Scutellariae Radix- Artemisiae Scopariae Herba, Gardeniae Fructus- Artemisiae Scopariae Herba, Glycyrrhizae Radix et Rhizoma- Artemisiae Scopariae Herba, etc. Based on the compatibility network, four clusters with close connection were obtained, including 23 Chinese medicines. According to the degree and closeness index, the core nodes of Artemisiae Scopariae Herba, Bovis Calculus, Carthami Flos, Glycyrrhizae Radix et Rhizoma, Aucklandiae Radix, Cyperi Rhizoma, Rhei Radix et Rhizoma, Bupleuri Radix, Salviae Miltiorrhizae Radix et Rhizoma were obtained. Conclusion:The combination of herbs and formula for treating icterus conforms to the TCM theory and clinical practice, which could provide reference for the treatment of icterus with TCM and related Chinese patent medicine research.