The predictive value of lung ultrasound score for bronchopulmonary dysplasia in preterm infants: a meta-analysis / 中国新生儿科杂志

ABSTRACT

Objective:To study the early predictive value of lung ultrasound score for bronchopulmonary dysplasia (BPD) in preterm infants with gestational age ≤32 w.Methods:From the establishment of the databases PubMed, Medline, Embase, Cumulative Index to Nursing and Allied Health (CINAHL), Cochrane Library, CNKI, CQVIP and Wanfang databases to February 17, 2022, studies on BPD with lung ultrasound score were searched. Literatures were screened according to the inclusion and exclusion criteria. The quality of the literature was evaluated and the eligible data were extracted. Stata 15.1 software was used for Meta-analysis.Results:Fourteen studies with a total of 1 645 preterm infants were included. The results showed that the sensitivity of the lung ultrasound score at 7 d of life predicting BPD was 0.71 (95% CI 0.64~0.77), the specificity was 0.83 (95% CI 0.74~0.89), and AUC was 0.81 (95% CI 0.78~0.84). At 14 d, the sensitivity was 0.64 (95% CI 0.59~0.69), the specificity was 0.89 (95% CI 0.72~0.96), and AUC was 0.68 (95% CI 0.64~0.72). Meta-analysis showed that sex, BA and birth weight were not sources of heterogeneity. Conclusions:Meta-analysis shows that lung ultrasound score has predictive value for BPD in preterm infants with GA ≤32 w, especially at 7 d of life. Lung ultrasound score is helpful in clinical decision-making.