Epigenetic regulation and retinal degenerative diseases / 中华实验眼科杂志

ABSTRACT

Epigenetics pertains to heritable alterations in gene expression when the nucleotide sequence remains unchanged.Epigenetic regulation mechanisms are diverse, among which DNA methylation, histone modification and non-coding RNA (ncRNA) regulation have been studied in depth.Epigenetic regulation is associated with a variety of human diseases.In the occurrence and development of retinal degenerative diseases, many epigenetic regulation processes such as DNA methylation, histone acetylation and ncRNA regulation have changed.DNA methylation is one of the important regulation processes in retinal degeneration.Aberrant DNA methylation patterns are associated with retinitis pigmentosa (RP), age-related macular degeneration (AMD), inflammation and oxidative stress.Histone acetylation is associated with RP, diabetic retinopathy (DR), glaucoma and retinal nerve ischemic injury.NcRNA is associated with RP, AMD, pathological angiogenesis, and DR.In this article, the application of epigenetic regulation in retinal degeneration was reviewed.