Procalcitonin and C-reactive protein levels in patients with genital ureaplasma urealyticum infection and analysis of related risk factors / 中国基层医药

ABSTRACT

Objective:To investigate the changes in procalcitonin (PCT) and C-reactive protein (CRP) levels in married women with genital ureaplasma urealyticum infection and analyze the risk factors of genital ureaplasma urealyticum infection.Methods:A total of 116 married women with genital ureaplasma urealyticum infection who received treatment in the First Affiliated Hospital of Wenzhou Medical University from January 2019 to December 2019 were included in the observation group. An additional 50 healthy married women who concurrently received physical examination in the same hospital were included in the control group. Serum levels of PCT and CRP were compared between the two groups. Questionnaire outcomes and the risk factors for genital ureaplasma urealyticum infection were subjected to univariate analysis and logistic regression analysis.Results:Serum levels of PCT and CRP in the observation group were (3.71 ± 0.64) μg/L and (34.26 ± 4.23) mg/L, respectively, which were significantly higher than those in the control group [(0.49 ± 0.16) μg/L, (4.84 ± 0.75) mg/L, t = 35.05, 48.76, both P < 0.001]. In the observation group, the proportions of women who used condom each time, who had no abortion, who had one sexual partner, who had first sexual intercourse at the age of ≥ 20 years, who had sexual intercourse ≤ 3 times/week, who had no history of unclean sexual contact, and who knew knowledge of genital ureaplasma urealyticum infection were 54.55%, 24.24%, 65.15%, 54.55%, 42.42%, 69.70%, 34.85%, respectively, which were significantly lower than those in the control group [80.00%, 48.00%, 88.00%, 76.00%, 66.00%, 94.00%, 60.00%, χ2 = 9.79, 9.33, 8.81, 6.89, 7.89, 11.56, 9.32, P = 0.002, 0.009, 0.003, 0.008, 0.005, 0.001, 0.002). Multivariate analysis showed that abortion frequency, number of sexual partners, age at first sexual intercourse < 20 years, frequency of sexual intercourse and history of unclean sexual contact were independent risk factors for genital ureaplasma urealyticum infection ( OR = 2.12, 3.58, 2.34, 2.84, 4.24). Frequent condom use and knowledge of genital ureaplasma urealyticum infection were protective factors for genital ureaplasma urealyticum infection ( OR = 4.03, 3.03). Conclusion:Abnormal increases in serum PCT and CRP levels in married women can be used as sensitive indicators for early diagnosis of genital ureaplasma urealyticum infection. Frequency of sexual intercourse, number of sexual partners, more times of abortion, premature sexual activity, and history of unclean sexual contact are the risk factors of genital ureaplasma urealyticum infection.